FORBES, John Richard,MORAN, Matthew David Burr,SIMMS, Ryan Wayne,VALLIANT, John Fitzmaurice
申请号：
USUS2018/031233
公开号：
WO2018/204872A3
申请日:
2018.05.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to conjugates including a chelating moiety of a metal complex thereof and a therapeutic or targeting moiety, methods for their production, and uses thereof. The present invention is directed to monoclonal antibodies that target the insulin-like growth factor-1 receptor and the radioimmunoconjugates thereof that demonstrate increased potency and enhance the excretion of a chelating moiety, or a metal complex thereof, when conjugated to a therapeutic moiety, a targeting moiety, or a cross-linking group. In another aspect, the invention features a pharmaceutical composition comprising a compound of the invention； and a pharmaceutically acceptable excipient. In another aspect, the invention features a method of radiation treatment planning and/or radiation treatment, the method comprising administering to a subject in need thereof a compound or pharmaceutical composition of the invention.La présente invention concerne des conjugués comprenant une fraction chélatante d'un complexe métallique de ceux-ci et une fraction thérapeutique ou de ciblage, des procédés pour leur production, et des utilisations associées.
