BURAK, ERIC STEVEN,FORBES, JOHN RICHARD,MORAN, MATTHEW DAVID BURR,SIMMS, RYAN WAYNE,VALLIANT, JOHN FITZMAURICE,DARWISH, ALLA
申请号：
CA3062538
公开号：
CA3062538A1
申请日:
2018.05.04
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to conjugates including a chelating moiety of ametal complex thereof and a therapeuticor targeting moiety, methods for their production, and uses thereof. Thepresent invention is directed to monoclonal antibodies thattarget the insulin-like growth factor-1 receptor and the radioimmunoconjugatesthereof that demonstrate increased potency and enhancethe excretion of a chelating moiety, or a metal complex thereof, whenconjugated to a therapeutic moiety, a targeting moiety, or across-linking group. In another aspect, the invention features apharmaceutical composition comprising a compound of the invention；and a pharmaceutically acceptable excipient. In another aspect, the inventionfeatures a method of radiation treatment planningand/or radiation treatment, the method comprising administering to a subjectin need thereof a compound or pharmaceutical compositionof the invention.
