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Feeder-free Derivation of human-induced pluripotent stem cells with synthetic messenger RNA
专利权人:
Allele Biotechnology & Pharmaceuticals, Inc.
发明人:
Wang Jiwu
申请号:
US201414292317
公开号:
US10119150(B2)
申请日:
2014.05.30
申请国别(地区):
美国
年份:
2018
代理人:
Duane Morris LLP
摘要:
The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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