VIKTOR LVOVICH LIMONOV,KONSTANTIN VALENTINOVICH GAIDUL,ALEKSANDR VALEREVICH DUSHKIN
申请号：
MX2012010535
公开号：
MX2012010535A
申请日:
2011.05.11
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
The invention relates to pharmacology, medicine, veterinary medicine and to the pharmaceutical industry, in particular to a process for preparing original composite antimicrobial preparations for parenteral administration which have increased therapeutic effectiveness in the treatment of severe forms of infectious and inflammatory diseases. The proposed pharmaceutical compositions comprise, as active ingredient, beta-lactam antibiotics and highly disperse nanostructured silicon dioxide in ratios of from 10:1 to 75:1 by weight, respectively. The silicon dioxide particles present in the composition are the means of supplying the molecules of the antibiotics to the phagocytes, which makes it possible to increase, in a targeted manner, the concentration of the antimicrobial preparations in the areas of inflammation and to substantially neutralize the phenomenon of antibiotic resistance of microorganisms. The claimed process for preparing a pharmaceutical composition consists in mixing a beta-lactam antibiotic substance with highly disperse nanostructured silicon dioxide and is characterized in that the mixture of the above-mentioned substances in ratios of from 10:1 to 75:1 by weight, respectively, is subjected to mechanical processing by means of impact abrasion until the proportion by weight of the finely disperse fraction (< 5 µm) is increased to at least 25%. The resultant mixture is used for preparing injection solutions.La presente invención se refiere a farmacología, medicina, veterinaria e industria farmacéutica. Se refiere en particular al procedimiento de producción de preparaciones antimicrobianas compuestas originales para aplicación externa, que presentan una eficacia terapéutica superior en el caso de enfermedades infecciosas e inflamatorias graves. Los agentes activos de las composiciones farmacéuticas propuestas son antibióticos de beta-lactama y dióxido de silicio nanoestructurado finamente disperso con una razón en peso de desde 10:1 hasta 75:1, respe
