GAIDUL KONSTANTIN, VALENTINOVICH,DUSHKIN ALEKSANDR, VALERIEVICH,Гайдуль, Константин Валентинович,Душкин, Александр Валерьевич
申请号：
EA201001449
公开号：
EA021874B1
申请日:
2010.09.13
申请国别(地区):
EA
年份:
2015
代理人:
摘要：
The invention relates to pharmacology, medicine, veterinary medicine and to the pharmaceutical industry, in particular to a process for preparing original composite antimicrobial preparations for parenteral administration which have increased therapeutic effectiveness in the treatment of severe forms of infectious and inflammatory diseases. The proposed pharmaceutical compositions comprise, as an active ingredient, beta-lactam antibiotics and fine nanostructured silicon dioxide in ratios of from 10:1 to 75:1 by weight, respectively. The silicon dioxide particles present in the composition are the means of supplying the molecules of the antibiotics to the phagocytes, which makes it possible to increase, in a targeted manner, the concentration of the antimicrobial preparations in the areas of inflammation and to substantially neutralize the phenomenon of antibiotic resistance of microorganisms. The claimed process for preparing a pharmaceutical composition consists in mixing a beta-lactam antibiotic substance with highly disperse nanostructured silicon dioxide and is characterized in that the mixture of the above-mentioned substances in ratios of from 10:1 to 75:1 by weight, respectively, is subjected to mechanical processing by means of impact abrasion until the proportion by weight of the finely disperse fraction (<；5 μm) is increased to at least 25 %. The obtained mixture is used for preparing injection solutions.Изобретение относится к фармакологии, медицине, ветеринарии и к фармацевтической промышленности, в частности к способу получения оригинальных композитных антимикробных препаратов для парентерального применения, которые обладают повышенной терапевтической эффективностью при лечении тяжёлых форм инфекционно-воспалительных заболеваний. Предложенные фармацевтические композиции содержат в качестве действующего вещества бета-лактамные антибиотики и высокодисперсный наноструктурированный диоксид кремния в соотношениях от 10:1 до 75:1 по весу соответственно. При
