Jianqi Li,Xiaowen Chen,Zhilong Ma,Li Zhang,Ning Cui
申请号：
US14889831
公开号：
US09550741B2
申请日:
2014.05.08
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed are benzoisothiazole compounds and a use in the preparation of anti-schizophrenia drugs. The benzoisothiazole compounds of the present invention not only have strong affinity for dopamine D3 receptor, 5-HT1A receptor and 5-HT2A receptor, but also can observably improve the symptoms of schizophrenia relevant to apomorphine model and MK-801 model mice, with oral absorption being good, safety being high and side-effect being less, and having developmental value as new anti-neurotic disease drugs. The present invention is the compounds having a structure of general formula (I), or geometric isomers, free alkalies, salts, hydrates or solvates thereof.
