DANG, ZHU,CAI, CHRISTINE JUE,LUO, ZHEN,WANG, LIUGANG,BAO, DAN
申请号：
CA3091555
公开号：
CA3091555A1
申请日:
2018.12.26
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention discloses a tetrahydropyrrole compound, a preparationmethod therefor, a pharmaceutical composition containing the same, and a usethereof. Thetetrahydropyrrole compound of the present invention is represented by generalformula (I).The tetrahydropyrrole compound of the present invention has better inhibitoryeffects on thepositive symptoms of schizophrenia, and the potency thereof is equivalent toor slightly strongerthan that of the positive drug olanzapine. In addition, the compound of thepresent inventionhas dual inhibitory effects on D2 receptors and DAT receptors, and iseffective for treatingschizophrenia and improving negative symptoms and cognitive functions, whilealso reducingvertebral side effects and prolactin secretion.
