DANG, Zhu,CAI, Christine Jue,LUO, Zhen,WANG, Liugang,BAO, Dan
申请号：
AU2018393409
公开号：
AU2018393409A1
申请日:
2018.12.26
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention discloses a tetrahydropyrrole compound, a preparation method therefor, a pharmaceutical composition containing the same, and a use thereof. The tetrahydropyrrole compound of the present invention is represented by general formula (I). The tetrahydropyrrole compound of the present invention has better inhibitory effects on the positive symptoms of schizophrenia, and the potency thereof is equivalent to or slightly stronger than that of the positive drug olanzapine. In addition, the compound of the present invention has dual inhibitory effects on D2 receptors and DAT receptors, and is effective for treating schizophrenia and improving negative symptoms and cognitive functions, while also reducing vertebral side effects and prolactin secretion.
