BOURKE, DAVID GERARD,BU, XIANYONG,BURNS, CHRISTOPHER JOHN,CUZZUPE, ANTHONY NICHOLAS,FEUTRILL, JOHN THOMAS,NERO, TRACY LEAH,BLANNIN, BEATA MARIA,ZENG, JUN,GAYNOR, SHAUN PATRICK
申请号：
CA2702647
公开号：
CA2702647C
申请日:
2008.01.31
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to thiopyrimidine-based compounds of formula Ithat areinhibitors of protein kinases including JAK kinases. In particular, thecompounds areselective for JAK1, JAK2 or JAK3 kinases and combinations thereof such as JAK1andJAK2. The kinase inhibitors can be used in the treatment of kinase associateddiseases suchas immunological and inflammatory diseases including organ transplants；hyperproliferativediseases including cancer and myeloproliferative diseases； viral diseases；metabolic diseasesand vascular diseases.(see formula above)
