FOSTER, KEITH ALAN,CHADDOCK, JOHN ANDREW,PURKISS, JOHN ROBERT,QUINN, CONRAD PADRAIG
申请号：
CA2383470
公开号：
CA2383470C
申请日:
2000.09.25
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
A method of treatment of disease by inhibition of cellular secretory processesis provided. The method has particular application in the treatment ofdiseases dependent upon the exocytotic activity of endocrine cells, exocrinecells, inflammatory cells, cells of the immune system, cells of thecardiovascular system, and bone cells. Agents and compositions therefor, aswell as methods for manufacturing these agents and compositions, are provided.In a preferred embodiment a clostridial neurotoxin, substantially devoid ofholotoxin binding affinity for neuronal cells of the presynaptic muscularjunction, is associated with a targeting moiety. The targeting moiety isselected such that the clostridial toxin conjugate so formed may be directedto a non-neuronal target cell to which the conjugate may bind. Followingbinding, a neurotoxin component of the conjugate, which is capable ofinhibition of cellular secretion, passes into the cytosol of the target cellby cellular internalisation mechanisms. Thereafter, inhibition of secretionfrom the target cell is effected.
