Disclosed are methods and dietary compositions for the treatment and prevention of neuropathic pain and for pain prognosis. Some embodiments may include the administration of a diet rich in omega-3 fatty acids. Methods for the treatment and prevention of neuropathic pain by administering a diet rich in omega-3 fatty acids, N-acylated ethanolamines, or N-acylated ethanolamine precursors are also provided. Compositions for the treatment and prevention of neuropathic pain are also provided.