GORSUCH, REYNOLDS G.,PETERS, HAROLD W.,HANDLEY, HAROLD H., JR.
申请号：
CA2463022
公开号：
CA2463022C
申请日:
2002.10.15
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
A filter device (10) for being implanted in a blood vessel for carrying out in-vivo plasma separation comprises one or more elongated hollow tubes (14, 16)and a plurality of elongated hollow microporous fibers (12), each fiber (12)having a first and second end secured to one or more of the elongated hollowtubes (14, 16) with the interior lumen of each of the fibers communicatingwith the interior of the one or more of the hollow tubes (14, 16), and whereinthe fiber wall has a higher mass density zone adjacent to the outer wallsurface and a lower mass density zone adjacent to the inner wall surface.Apparatus for carrying out therapeutic apheresis includes the filter device(10), a multiple lumen catheter (20) secured to the proximal end of the filterdevice (10) having one or more lumens in fluid communication with the interiorof said one or more hollow tubes (14, 16) and a plasma return lumen (52), andtherapeutic apheresis apparatus (40) for removing and/or separating selecteddisease-related components from the separated plasma and means for directingplasma between said catheter and the selective component removal apparatus.
