A method for obtaining a mixture of biological factors isolated from colostrum, comprising the steps of: a) microdiafiltration of whole colostrum, previously diluted with water or with a saline aqueous solution comprising pharmaceutically acceptable ions so as to yield a volume V1, the microdiafiltration comprising at least one step of filtering the diluted whole colostrum through a cylindrical ceramic membrane with a porosity comprised between 2 and 6 microns, at a temperature comprised between 2°C and 20°C, and at a transmembrane pressure (tmp) comprised between 0.2 bar and 2 bar, obtaining a retentate fraction and a permeate fraction b) collecting the resulting permeate until its total volume V2 amounts to at least 40% of the volume V1 of initial diluted whole colostrum c) optional sterilizing filtration of the permeate and d) optional removal of the water contained in the permeate. The invention also relates to a mixture of biological factors isolated from colostrum which comprises the following quantities of the following active factors, indicated per mg of dry product: 0.15 - 0.35 mg of IgG 0.01 - 0.05 mg of IgA 0.5 - 3.0 ng of IGF-1 30 - 90 pg of TGF β1. The invention also relates to a nutraceutical formulation that comprises the mixture according of the invention and a supplement for milk for newborns, or for follow-on milk or growth milk, or for drinking milk, comprising the mixture of the invention. Finally, the invention relates to milk for newborns, or follow-on milk or growth milk, both in powder form and reconstituted, or drinking milk, supplemented with the mixture of the invention.Linvention porte sur un procédé permettant dobtenir un mélange de facteurs biologiques isolés à partir de colostrum, comprenant les étapes suivantes : a) la micro-diafiltration de colostrum entier, préalablement dilué avec de leau ou avec une solution aqueuse saline comprenant des ions pharmaceutiquement acceptables afin de produire un volume V1, la micro-diafiltration comp
