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THERAPY BASED ON MODULATION OF IMMUNODOMINANCE
专利权人:
ЭлЭлСи (US);ДЖИНЕИУС БАЙОТЕКНОЛОДЖИ ИНВЕСТМЕНТС
发明人:
СЛАНЕТЦ Альфред Э. (US)
申请号:
RU2013157923/10
公开号:
RU2013157923A
申请日:
2012.05.25
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A T cell capable of recognizing a subdominant antigen or epitope in a patient for use in a method for changing the hierarchy of immunodominance of a patient. A T cell for use according to claim 1, wherein the T cell is obtained by: a. identifying at least one subdominant antigen or epitope in a sample taken from a patient, and b. culturing T cells that can recognize the indicated subdominant antigen or epitope. 3. A T cell for use according to claim 1 or 2, wherein changing the hierarchy of immunodominance treats / prevents / attenuates infection, cancer, inflammation, rejection of a transplanted organ, or transplant reaction against a host in a patient. Use of a T cell capable of recognizing a subdominant antigen or epitope in a patient upon receipt of a medicament for changing the hierarchy of immunodominance in a patient. 5. The use of claim 4, wherein the T cell is obtained by: a. identifying at least one subdominant antigen or epitope in a sample taken from a patient, and b. culturing a T cell capable of recognizing said subdominant antigen or epitope. 6. The use of claim 4 or 5, wherein changing the hierarchy of immunodominance treats / prevents / attenuates infection, cancer, inflammation, rejection of a transplanted organ, or transplant versus host reaction in a patient. A population of T cells for use when changing the hierarchy of immunodominance in a patient, obtained by identifying at least one subdominant antigen or epitope in a sample taken from a patient and cultivating a population of T cells capable of recognizing said subdominant ant1. Т-клетка, способная распознавать субдоминантный антиген или эпитоп у пациента, для применения в способе изменения иерархии иммунодоминантности пациента.2. Т-клетка для применения по п. 1, где Т-клетка получена посредством:a. идентификации по меньшей мере одного субдоминантного антигена или эпитопа в образце, взятом от пациента, иb. культивирования Т-клеток, которые могут распознавать указанный субдоминантный антиг
来源网站:
中国工程科技知识中心
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