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Therapeutic strategy to treat autoimmune and degenerative diseases
专利权人:
IMMUNAID PTY LTD
发明人:
ASHDOWN, MARIA,ASHDOWN, MARTIN
申请号:
ES05777835
公开号:
ES2383103T3
申请日:
2005.09.08
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A method to analyze the immune system cycle to determine when an agent should be administered to a patient suffering from a disease characterized by the production of effector T cells or a degenerative disease, the method comprises monitoring the patient, or samples obtained from the same, for fluctuations in at least one of: a) effector T cell numbers and / or activity, b) regulatory T cell numbers and / or activity, c) a marker molecule associated with the disease, and / od) a immune system marker; where if the disease is characterized by the production of effector T cells: (i) the disease is an autoimmune disease or transplant rejection; (ii) the agent inhibits production, limits the function of and / or activity of effector T cells and is selected from the group consisting of anti-proliferative drugs, anti-metabolic drugs, radiation, dsRNA and antibodies; and (iii) the time when the agent must be administered is when, or just before, the effector T cells expand clone so that no effector T cell expansion occurs, and / or the effector T cell numbers are reduced or eliminate; and where if the disease is a degenerative disease: (i) the disease is a condition that results in the loss of cells, and is Alzheimer's disease or a prion-related disease; and (ii) the agent: (a) inhibits production, limits the function of and / or activity of regulatory T cells and is selected from the group consisting of anti-proliferative drugs, anti-metabolic drugs, radiation, dsRNA, and antibodies ; and the time when the agent must be administered is such that the agent exerts a proportionately greater effect against regulatory T cells than effector T cells; or (b) is a vaccine; and the time when the vaccine should be administered is such that the vaccine reinforces the innate immune response, which produces an increase in the numbers and / or activity of effector T cells, before the emergence of regulatory T cells.Un método para analizar el ciclo del sistema inmunitario para determinar
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