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AGONISTS THAT ENHANCE BINDING OF INTEGRIN-EXPRESSING CELLS TO INTEGRIN RECEPTORS
专利权人:
TEXAS HEART INSTITUTE
发明人:
BIEDIGER, RONALD, J.,GUNDLACH, IV, C., WILLIAM,MARKET, ROBERT, V.,SAVAGE, MICHAEL, M.,VANDERSLICE, PETER
申请号:
EP11841201
公开号:
EP2640721A4
申请日:
2011.11.16
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
A method of enhancing binding of cells to an integrin-binding ligand comprises treating integrin-expressing cells in vitro with an agonist of integrin, wherein the integrin is selected from the group consisting of ±4²1, ±4²1, ±4²7, ±4²3 and ±L²2, and contacting the treated cells with an integrin-binding ligand integrin agonist compounds having the general formula I methods of treating integrin-expressing cells with such agonists to enhance binding and therapeutic methods comprising administering agonist-treated cells or agonist compounds to a mammal.
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