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Agonists that enhance the binding of integrin-expressing cells to integrin receptors
专利权人:
Texas Heart Institute
发明人:
Biediger, Ronald, J.,Gundlach, IV, William, C.,Market, Robert, V.,Savage, Michael, M.,Vanderslice, Peter
申请号:
DK14191381
公开号:
DK2881393T3
申请日:
2011.11.16
申请国别(地区):
DK
年份:
2018
代理人:
摘要:
A method of enhancing binding of cells to an integrin-binding ligand comprises treating integrin-expressing cells in vitro with an agonist of integrin, wherein the integrin is selected from the group consisting of ±4²1, ±4²1, ±4²7, ±4²3 and ±L²2, and contacting the treated cells with an integrin-binding ligand; integrin agonist compounds having the general formula I; methods of treating integrin-expressing cells with such agonists to enhance binding; and therapeutic methods comprising administering agonist-treated cells or agonist compounds to a mammal.
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