BLASCZYK, Rainer,FERREIRA DE FIGUEIREDO, Constanca
申请号：
WO2018EP63581
公开号：
WO2018215571(A1)
申请日:
2018.05.23
申请国别(地区):
世界知识产权组织国际局
年份:
2018
代理人:
摘要：
The invention provides an ex-vivo method, i.e. an in vitro method, for genetically modifying cells of a vascularised tissue, which can be anorgan, during normothermic or subnormothermic perfusion without damaging the tissue or its cells due to oxygen undersupply. The method enables keeping the vascularised tissue at normothermic or subnormothermic conditions over a sufficient period of time to genetically modify the cells e.g. with viral vectors.
