PROSPECT CHARTERCARE RWMC; LLC D/B/A ROGER WILLIAMS MEDICAL CENTER
发明人:
KATZ, STEVEN C.,凯兹 史帝芬,凱茲 史帝芬,JUNGHANS, RICHARD P.,琼汉斯 理查,瓊漢斯 理查,凯兹 史帝芬,凱茲 史帝芬,琼汉斯 理查,瓊漢斯 理查
申请号：
TW105111666
公开号：
TW201708542A
申请日:
2016.04.14
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
Disclosed herein are compositions and methods for the treatment of liver metastases in a subject. The methods include hepatic arterial infusion (HAI) of chimeric antigen receptor modified T cells (CAR-T) which are highly specific for tumor antigens such as carcinoembryonic antigen (CEA). The HAI method is optimized to maximize exposure of the modified cells to the metastatic cells while minimizing exposure to healthy cells. The methods include co-administration of a second therapeutic agent, such as IL-2.本發明係揭露用於治療個體中肝轉移的組成物與方法。該方法包含嵌合抗原受體修飾的T細胞(chimeric antigen receptor modified T cell，CAR-T)之肝動脈灌注(hepatic arterial infusion，HAI)，該嵌合抗原受體修飾的T細胞對於腫瘤抗原有高特異性，該腫瘤抗原例如癌胚抗原(carcinoembryonic antigen，CEA)。該HAI方法係被優化以最大化該修飾細胞暴露於轉移細胞，同時最小化暴露於健康細胞。該方法包含第二治療劑，例如IL-2，的共同投予。
