A pedicle screw locking and derotation instrument, comprising: an elongate actuation mechanism, wherein the elongate actuation mechanism comprises a pair of elongate arms that are pivotably hinged to one another and comprise a pair of handle portions and a pair of clamp members coupled to the elongate actuation mechanism and deployed by actuation of the elongate actuation mechanism wherein each of the pair of clamp members comprises a retention portion configured to selectively and securely engage a threaded shaft of a pedicle screw and a portion configured to selectively and securely engage a head body of the pedicle screw, thereby holding the threaded shaft and the head body in rigid alignment wherein each of the pair of clamp members comprises a retention portion that is configured to be selectively disposed beneath the head body of the pedicle screw and about the threaded shaft of the pedicle screw.