Jiangsu Hengrui Medicine Co., Ltd.;Shanghai Hengrui Pharmaceutical Co., Ltd.
发明人:
Xin LI,Qing DONG,Piaoyang SUN
申请号：
US15531525
公开号：
US20170342059A1
申请日:
2015.11.10
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Pyridinecarboxamide derivatives, preparation methods, and a pharmaceutical uses thereof are provided. In particular, pyridinecarboxamide derivatives represented by general formula (I), wherein the substituents of the formula (I) are defined in the specification are provided. Also provided are a preparation method for the pyridinecarboxamide derivatives of formula (I), a pharmaceutical composition containing the pyridinecarboxamide derivatives, and uses of the pyridinecarboxamide derivatives as therapeutic agents, especially as inhibitors of the Renal Outer Medullary Potassium channel (ROMK) and in the preparation of medicaments for treating and/or preventing hypertension and heart failure.
