FIELD: chemistry.SUBSTANCE: invention relates to novel pyrrolopyrimidines of formula (I) and pharmaceutically acceptable salts and solvates thereof, having IGF-IR and IR inhibiting properties, which can be used to treat proliferative cancerous diseases such as breast cancer, sarcoma, lung cancer and prostate cancer. In the compound of formula (I): R1 is selected from H and C1-C3alkyl R2 is selected from H, C1-C3alkyl and halogen R3 is selected from H, OH, C1-C6alkyl, groups -C1-C6alkylene-OH, -C1-C6alkylene-phenyl (optionally substituted with a halogen) and -C1-C6alkylene-C(O)NH2 R4 is selected from H, halogen, C1-C6alkyl and -O-C1-C6alkyl or R3 and R4, together with atoms with which they are bonded, form a 5- or 6-member lactam each of R5 and R6 is independently selected from H, halogen, C1-C6alkyl and -O-C1-C6alkyl, or R5 and R6 together with an aryl with which they are bonded form naphthalene R7 is selected from C1-C6alkyl, -O-C1-C6alkyl, halogen, -N-R19R19 and -O-C1-C6alkylene-halogen R8 is selected from H, halogen and C1-C6alkyl one of R9 and R10 is selected from -C1-C6alkylene-SO2-C1-C6alkyl, -NR19-C(O)-C0-C6alkylene-NR22R23, -O- C0-C6alkylene(optionally substituted with -OH)-NR22R23, and etc, given in the claim and the other of R9 and R10 is selected from H, C1-C6alkyl, -O- C1-C6alkyl and halogen.EFFECT: improved method.41 cl, 12 dwg, 263 exИзобретение относится к новым пирролопиримидинам формулы (I) и их фармацевтически приемлемым солям и сольватам, обладающим свойствами ингибитора рецептора IGF-1R и IR, которые могут найти применение для лечения раковых пролиферативных заболеваний, таких как рак молочной железы, саркома, рак легкого, рак предстательной железы. В соединении формулы (I):R1 выбран из H и С1-С3алкила R2 выбран из Н, C1-C3алкила и галогено R3 выбран из Н, ОН, C1-C6алкила, групп -C1-C6алкилен-ОН, -C1-C6алкилен-фенил (возможно замещенной галогено) и -C1-C6алкилен-С(O)NН2 R4 выбран из Н, галогено, C1-C6алкила и группы -O-C1-C6алкил или R3 и R4 в
