Mayo Foundation for Medical Education and Research
发明人:
Edward B. Leof,Mark C. Wilkes,Claire E. Repellin,Jeong-Han Kang,Xueqian Yin,Mahefatiana Andrianifahanana
申请号：
US15426455
公开号：
US10144929B2
申请日:
2017.02.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This document provides polypeptide inhibitors of Smad3 polypeptide activities. For example, methods and materials for using polypeptides (e.g., polypeptides designed to include both a cell penetrating amino acid sequence and an amino acid segment of a SH3 domain of a SNX9 polypeptide) to inhibit one or more Smad3 polypeptide activities are provided. This document also provides methods and materials for using RNA interference to treat a disease (e.g., a fibrotic disease) in a mammal (e.g., a human).
