THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
发明人:
Ying Chau,Yu Yu,Jieying Zhong
申请号：
US14782999
公开号：
US20160038599A1
申请日:
2014.04.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides compositions, and related kits and methods, for formation of hydrogels. The compositions comprise one or more chemically crosslinkable agents dissolved in an aqueous solution to form a precursor solution. The chemically crosslinkable agents useful in the present invention are selected from polymers modified with a molecule selected from acrylate, maleimide, vinylsulfone, N-hydroxysuccinimide, aldehyde, ketone, carbodiimide, carbonate, iodoacetyl, mercaptonicotinamide, quinone, thiol, amine, and combinations thereof. The precursor solution is characterized as being in an aqueous form at a non-physiologic physical-chemical condition and undergoing gelation when in contact with another fluid or body at a physiologic physical-chemical condition.
