WAKSAL, SAMUEL D.,ZHU, ZHENPING,WU, YAN,MARTOMO, STELLA A.,ZHONG, ZHAOJING,LU, DAN
申请号：
CA2936543
公开号：
CA2936543A1
申请日:
2015.01.15
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention provides antibodies that specifically bind to PD-Ll and fusion molecules comprising PD-Ll binding proteins constructed with an IL15 receptor-binding domain, nucleic acid molecules encoding the same, and therapeutic compositions thereof. The agents inhibit PD-Ll -mediated immunosuppression and enhance cell and cytokine mediated immunity for the treatment of neoplastic and infectious diseases.
