Samuel WAKSAL,Zhenping ZHU,Yan WU,Stella MARTOMO,Zhaojing ZHONG,Dan LU
申请号：
US15111102
公开号：
US20160340429A1
申请日:
2015.01.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention provides antibodies that specifically bind to PD-L1 and fusion molecules comprising PD-L1 binding proteins constructed with an IL15 receptor-binding domain, nucleic acid molecules encoding the same, and therapeutic compositions thereof. The agents inhibit PD-L1-mediated immunosuppression and enhance cell and cytokine mediated immunity for the treatment of neoplastic and infectious diseases.
