Highly Soluble N-P-K Fertilizer with Seaweed extract and Spirulina for use in Agriculture. A water soluble N-P-K fertilizer composition that combines the benefits of Seaweed extract containing naturally occurring trace and microelements and Spirulina containing amino acids with a neutral pH and free from Chlorides is prepared. The inventive product is highly water soluble and therefore offers the benefit of easy absorption as compared to conventional water soluble fertilizers. Being neutral in pH it not harmful to the soil microbes unlike conventional fertilizers and it combines the benefits of seaweed extract and Spirulina that offers many microelements and trace elements and amino acids respectively while promoting soil microbes. The product is prepared by grinding and mixing the sources of Nitrogen, phosphorous and potassium namely Urea, potassium phosphate dibasic, tri potassium phosphate, potassium nitrate, phosphorous acid crystal, spirulina and seaweed extract to obtain the desired N-P-K ratio. Various combinations of the above ingredients can be made to make N-P-K ratios suitable for Vegetable and Fruit crops to be applied at different intervals. The ingredients being completely water soluble, the solution does not block or clog the Spraying equipments. This NPK Fertilizer can be dissolved in water and applied to vegetable, fruit and field crops to provide them N-P-K along with amino acids, microelements and trace elements.