The present invention provides an indirect method and associated device for delivering high concentrations of drugs, particularly antibiotics, to the nasal sinus by first loading the drugs into the cerebrospinal vein system (CVCS) via Valsalva maneuver. Since CVCS is a valveless and three-dimensional closed system, traditional physiological dogmas such as veins that always leak tissue are not always applicable. Instead, because of its closed system, blood can flow in any direction, CVCS's blood and any drugs it contains are highly sinus from the veins that exist during nasal allergies or nasal infections. Where there is increased spillage, such as drainage, it is drawn to any part of it. Thus, nasal obstruction that delays the effectiveness of direct drug administration, such as that seen with systemic administration of nasal inhalers or antibiotics, serves to indirectly administer drugs to the nasal sinus via CVCS. Furthermore, the present method, unlike the present therapy, has the benefit of drug delivery, not limited to drugs that can be continuously absorbed from the gastrointestinal tract. This means that in the case of antibiotics, bacteria infected with this part of the CVCS are not as resistant to treatment if not previously exposed to this new family of antibiotics. . Finally, if the infection reaches the eardrum and the Valsalva maneuver becomes painful, or if the patient is abnormally sensitive, wear earplugs to reduce stress on the eardrum while the patient performs Valsalva maneuver be able to.本発明は、最初に薬剤を脳脊髄静脈系（ＣＶＣＳ）にバルサルバ操作を介して装荷することで鼻洞に高濃度の薬剤、特に、抗生物質を供給する間接方法及びそれに伴う装置を提供する。ＣＶＣＳは無弁で三次元的閉鎖系であるため、常に組織を漏出する静脈などの伝統的な生理学なドグマは常には適用できない。代わりに、その閉鎖系で血液は任意の方向に流れることができるため、ＣＶＣＳの血液及びそれが包含する任意の薬剤は、鼻アレルギー又は鼻の感染症の間に存在する多量の静脈由来の洞液排液などの増大した流出があるところでは、その任意の部分に引かれる。このように、鼻吸入器又は抗生物質の全身投与で見られるような直接薬剤投与の有効性を遅延させる鼻閉が、ＣＶＣＳを介して鼻洞に薬剤を間接的投与するのに役立つ。さらに、本方法は、本治療法と異なり、消化管から連続的に吸収され得る薬剤だけに限られない薬剤の送達の利益を有する。これは、抗生物質の場合、ＣＶＣＳのこの部分に感染したバクテリアは、この新しい系統の抗生物質に以前に晒されていない場合には、治療に対してさして抵抗性を有さな
