The present invention relates to a novel therapy regimen for the treatment of severe acne related diseases preferentially severe or nodular acne. The novel therapy regimen adds a topical fixed-dose combination of a retinoid and an anti-bacterial agent, such as benzoyl peroxide, to a course of oral antibiotic therapy using a daily dose of antibiotic ranging from 150mg to 300 mg per day. The invention also relates to a fixed-dose combination of a retinoid and an anti-bacterial agent for its use in said therapy regimen, and to a kit suitable for implementing such therapy.