Provided is an optimized decision-making system for multiple ore dressing production indexes based on a cloud server and mobile terminals, including mobile intelligent terminals, a cloud server, a mobile industrial private cloud server, a collecting computer and process controllers PLC or DCS. The mobile industrial private cloud server calculates out multiple decision-making result solution sets; the intelligent mobile terminals determine the final decision-making results; the mobile industrial private cloud server calculates out process control set values; the mobile intelligent terminals determine the final process control set values; and the process controllers PLC or DCS control equipment on a production line for production according to the final process control set values. The present invention further provides an optimized decision-making method for multiple ore dressing production indexes adopting the optimized decision-making system.