585674 Disclosed is the use of a plurality of influenza virus antigens in the manufacture of a medicament for vaccinating a subject against multiple clades of H5, influenza virus, said multi-dose medicament comprising a first dosage unit comprising hemagglutinin antigen from a first clade of H5 influenza A virus and a second dosage unit comprising hemagglutinin antigen from a second clade of H5 influenza A virus, wherein the first and second clades are different from each other. Further disclosed is the use of an immunogenic composition comprising hemagglutinin antigen from a second clade of H5 influenza A virus in the manufacture of a medicament for vaccinating against multiple clades of H5 influenza virus in a subject immunized previously with an immunogenic composition comprising hemagglutinin from a first clade of H5 influenza A virus. Also disclosed is an immunogenic composition for vaccinating a subject against multiple clades of H5 influenza virus, said immunogenic composition comprising hemagglutinin antigens from more than one clade of H5 influenza virus, and a kit comprising said composition.
