The present invention describes a method to improve the weight loss, the emphysema, the infiltration of inflammatory cells in lung tissues, the thickening of the tracheal wall, the pulmonary fibrosis, and abnormal lung function, which caused by chronic obstructive pulmonary disease, by administering the probiotic bacterium Parabacteroides goldsteiniitoa subject. The bacterium Parabacteroides goldsteinii can also modulate the expression of genes involved in lung fibrosis and mitochondrial activity in lung tissue. The bacterium Parabacteroides goldsteiniican therefore be used to treat chronic obstructive pulmonary disease.本發明提供一種戈氏副擬桿菌(Parabacteroides goldsteinii)之用途，該戈氏副擬桿菌可改善動物或人類因慢性阻塞性肺病導致之體重下降、肺氣腫、肺臟組織中發炎細胞的浸潤現象、氣管壁變厚增生、肺纖維化、以及肺功能異常，其亦可調控肺臟組織中與肺臟纖維化及粒線體活性相關之基因的表現量。因而可利用於慢性阻塞性肺病之治療以及相關醫藥組成物的製備。
