NAKDONGGANG NATIONAL INSTITUTE OF BIOLOGICAL RESOURCES
发明人:
KIM, SANG CHEOLKR,김상철,KIM, YEONG SUKR,김영수,JEONG, SANG CHULKR,정상철,HAN, WOONGKR,LEE, SEUNG YOUNGKR,이승영,YU, SANG MIKR,유상미,JIN, HYUN MIKR,진현미,KANG, CHANG HEEKR,강창희,LEE, HAN SOLKR,이한솔,HWANG, HYE JINKR,황혜진
申请号：
KR1020160115789
公开号：
KR1020180028288A
申请日:
2016.09.08
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
Disclosed is an anti-inflammatory composition using an extract of a novel microalgae Schizochytrium sp. PB-31 strain, when treated with a mouse macrophage cell line RAW264.7 cell stimulated with an inflammatory factor lipopolysaccharide (LPS), which has the activity of inhibiting the production of nitric oxide in a concentration-dependent manner, and inhibiting the production of PGE 2 and inflammatory cytokines such as TNF-&alpha, IL-6 and IL-1&beta.COPYRIGHT KIPO 2018본 발명은 염증 인자인 LPS(Lippolysaccharide)로 자극된 마우스 대식세포주인 RAW264.7 cell에 처리될 때 농도 의존적으로 산화질소(Nitric oxide)의 생성을 억제하고 PGE2와 염증성 사이토카인(TNF-α, IL-6, IL-1β)의 생성을 억제하는 활성을 가진, 신규 미세조류 시조카이트리움 속(Schizochytrium sp.) PB-31 균주 추출물을 이용한 항염증용 조성물 등을 개시한다.
