Symrise AG;Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
发明人:
Ley, Jakob Peter, Dr.,Backes, Michael, Dr.,Vössing, Tobias,Stähler, Frauke, Dr.,Meyerhof, Wolfgang, Prof. Dr.,Wintermeyer, Christian
申请号：
EP10169426.3
公开号：
EP2292224B1
申请日:
2010.07.13
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Use of precursor compound of a sweet taste receptor antagonist, preferably taste receptor type 1 member 2 (T1R2)/taste receptor type 1 member 3 (T1R3)-receptor antagonist or a mixture of two or more precursor compounds of one or more different sweet taste receptor-antagonists, to prevent or treat diseases, especially diabetes, particularly diabetes type 2 is new, where the precursor compound is not 2-(4-methoxy-phenoxy)-propionic acid 3-[2-(4-methoxy-phenoxy)-propionyloxy]-propyl ester and/or 5-{6-(4-methoxy-phenoxy)-1,2,3-tris-[2-(4-methoxy-phenoxy)-propionyloxy]-5-oxo-heptyl}-2-methyl-furan-3-carboxylic acid methyl ester. Independent claims are included for: (1) lactisole-precursor compound of formula (I) or its mixture, where (I) excludes the following compounds: (I； R = methyl, ethyl or butyl), 2-(4-methoxy-phenoxy)-propionic acid 3-[2-(4-methoxy-phenoxy)-propionyloxy]-propyl ester, 5-{6-(4-methoxy-phenoxy)-1,2,3-tris-[2-(4-methoxy-phenoxy)-propionyloxy]-5-oxo-heptyl}-2-methyl-furan-3-carboxylic acid methyl ester, 2-(4-methoxy-phenoxy)-propionic acid 4'-hydroxy-biphenyl-4-yl ester, 4-(6-acryloyloxy-hexyloxy)-benzoic acid 4'-[2-(4-methoxy-phenoxy)-propionyloxy]-biphenyl-4-yl ester, 4-(11-acryloyloxy-undecyloxy)-benzoic acid 4'-[2-(4-methoxy-phenoxy)-propionyloxy]-biphenyl-4-yl ester, 2-(4-methoxy-phenoxy)-propionic acid 4'-benzyloxy-biphenyl-4-yl ester, 2-(4-methoxy-phenoxy)-propionic acid 2-methyleneaminooxy-ethyl ester, 2-(4-methoxy-phenoxy)-propionic acid 4,4-dimethyl-2-oxo-1-phenyl-pyrrolidin-3-yl ester, and 2-(4-methoxy-phenoxy) -propionic acid 2,6-di-tert-butyl-4-methyl-phenyl ester； and (2) a nutrition-, consumable- or semi-finished preparation comprising the precursor compound or its mixture, and/or one or more further components (A). R : aliphatic or aromatic residue or a group comprising one or more O, preferably OH, ester or ether group. [Image] ACTIVITY : Antidiabetic. MECHANISM OF ACTION : T1R2 receptor antagonist； T1R3 receptor antagonist.
