БАРГ Хайко (DE),ФРИДРИХ Йозеф (DE),ЛИБЕТРАУ Вольфганг (DE),ВОЙГТС Роберт Дж. (US),ЛИГМЕН Тим Стефен (US)
申请号：
RU2015101105
公开号：
RU2015101105A
申请日:
2013.06.14
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A method of obtaining a gel composition comprising a crosslinked first polymer, optionally a second polymer, which may be crosslinked or uncrosslinked, and water, wherein the first and second polymer are selected from a polysaccharide comprising at least steps (i) to (iv): (i) crosslinking the mixture comprising the first polymer and water； (ii) after crosslinking in step (i) completion of crosslinking； (iii) optionally mixing the product obtained in step (ii) with the second polymer； (iv) dialysis of the product obtained in step (ii) or in step (iii) .2. The method of claim 1, wherein the first and second polymer may be the same polymer or may differ from each other. The method of claim 1, wherein the second polymer is crosslinked. The method of claim 1, wherein the first and second polymer are selected from hyaluronic acid and / or its sodium salt. The method according to PP. 1-3, in which the first polymer used in stage (i) has a molecular weight Mw in the range from 2.5 MDaltons to less than 3.0 MDaltons. 6. The method according to PP. 1-3, in which the second polymer used in stage (iii) has a molecular weight of at least 3.0 MDaltons. The method according to PP. 1-3, in which the mass of the second polymer is less than 5% by weight of the first polymer, or less than 4%, for example, is in the range from 0.01% to 5%, or is in the range from 0.1% to 4 %, or is in the range from 0.1% to 2.5%, or is in the range from 0.2% to 2.0%, or is in the range from 0.5% to 1.5% .8. The method according to PP. 1-3, further comprising step (v) :( v) adding an anesthetic or antiarrhythmic agent, such as lidocaine, or lidocaine hydrochloride, or lidocaine hydrochloride monohydrate, or tetracaine, or lidocaine and tetracaine, to the product obtained in step (iv) .9. The method according to PP. 1-3, further comprising step (vi) :( vi) filling the syringe with the product obtained1. Способ получения композиции в форме геля, включающей сшитый первый полимер, необязательно второй п
