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METHODS OF COMBINED THERAPY FOR TREATMENT OF PROLIFERATIVE DISEASES
专利权人:
АБРАКСИС БАЙОСАЙЕНС; ЭлЭлСи (US)
发明人:
ДИСЭЙ Нейл П. (US),СООН-ШИОНГ Патрик (US)
申请号:
RU2012156903/15
公开号:
RU2012156903A
申请日:
2011.05.20
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of treating a proliferative disease in an individual, comprising administering to the individual: a) an effective amount of a composition containing nanoparticles containing a taxane and a carrier protein, and b) an effective amount of at least one other agent that modifies the epigenetics in the cell. 2. The method of claim 1, wherein said other agent is a histone deacetylase inhibitor. The method of claim 2, wherein said other agent is a vorinostat. The method according to claim 3, further comprising administering to said individual a platinum-based agent. The method according to claim 1, wherein said other agent is a DNA methyl transferase inhibitor. The method of claim 5, wherein the other agent is azacytidine. The method of claim 5, wherein the other agent is decitabine. A method according to any one of claims 1 to 7, wherein the proliferative disease is a malignant tumor. The method of claim 8, wherein the cancer is breast cancer. The method according to claim 9, in which the individual is negative in relation to ER, PR or HER2.11. The method of claim 10, wherein the individual is negative with respect to ER, PR, and HER2.12. The method of claim 8, wherein the cancer is ovarian cancer. The method of claim 8, wherein the malignant tumor is non-small cell lung cancer. The method of claim 8, wherein the cancer is endometrial cancer. The method of claim 8, wherein the cancer is cervical cancer. The method of claim 8, wherein the cancer is pancreatic cancer. The method of claim 8, wherein the evil1. Способ лечения пролиферативного заболевания у индивидуума, включающий в себя введение индивидууму:a) эффективного количества композиции, содержащей наночастицы, содержащие таксан и белок-носитель, иb) эффективного количества, по меньшей мере, одного другого средства, которое модифицирует эпигенетику в клетке.2. Способ по п.1, в котором указанным другим средством является ингибитор деацетилазы гистонов.3. Способ по п.2, в котором указанным другим средством яв
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