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2-Oxyquinoline-3-substituted carboxamides as modulators of KCNQ2 / 3
专利权人:
GRÜNENTHAL GMBH
发明人:
KÜHNERT, SVEN,BAHRENBERG, GREGOR,KLESS, ACHIM,SCHRÖDER, WOLFGANG
申请号:
ES11754833
公开号:
ES2537628T3
申请日:
2011.08.26
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Substituted compound of general formula (I) wherein R1 represents an unsubstituted or mono- or polysubstituted aliphatic group (C1-10); a cycloaliphatic group (C3-10) or a heterocycloaliphatic group of 3 to 10 members, in each case unsubstituted or mono- or polysubstituted and in each case optionally linked through an aliphatic group (C1-8), which at its It may not be substituted or mono- or polysubstituted; aryl or heteroaryl, in each case unsubstituted or mono- or polysubstituted and in each case optionally linked through an aliphatic group (C1-8), which in turn may not be substituted or be mono- or polysubstituted; R2 represents H; F; Cl; Br; I; CN; CF3; C (>; = O) H; NO2; OCF3; SCF3; an aliphatic group (C1-4), C (>; = O) - aliphatic (C1-4), C (>; = O) -O-aliphatic (C1-4), C (>; = O) -NH-aliphatic ( C1-4), C (>; = O) -N (aliphatic (C1-4)) 2, the aliphatic group (C1-4) being able in each case not to be substituted or to be mono- or polysubstituted; an O-aliphatic (C1-4), OC (>; = O) -aliphatic (C1-4), S-aliphatic (C1-4), S (>; = O) 2-aliphatic (C1-4), S group (>; = O) 2-O-aliphatic (C1-4), the aliphatic group (C1-4) being able in each case not to be substituted or mono- or polysubstituted; a cycloaliphatic group (C3-6) or a heterocycloaliphatic group of 3 to 6 members, in each case unsubstituted or mono- or polysubstituted and in each case optionally linked through an aliphatic group (C1-4), which in turn it may not be substituted or be mono- or polysubstituted; R3, R4, R5 and R6 represent in each case, independently of each other, H; F; Cl; Br; I; CN; CF3; C (>; = O) H; C (>; = O) -OH; C (>; = O) -NH2; SCF3; S (>; = O) 2-OH; NO2; OCF3; an aliphatic group (C1-4), C (>; = O) -aliphatic (C1-4), C (>; = O) - O-aliphatic (C1-4), C (>; = O) -NH-aliphatic ( C1-4), C (>; = O) -N (aliphatic (C1-4)) 2, the aliphatic group (C1-4) being able in each case not to be substituted or to be mono- or polysubstituted; an O-aliphatic (C1-4), OC (>; =
来源网站:
中国工程科技知识中心
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