HUNG, FAN NGAI,孔 繁毅,ZHANG, JINXIA,张 锦霞,張 錦霞,TO, KAI WANG KELVIN,杜 启泓,杜 啟泓,LAU, JOHNSON YIU-NAM,刘 耀南,劉 耀南,YUEN, KWOK YUNG,袁 国勇,袁 國勇,孔 繁毅,张 锦霞,張 錦霞,杜 启泓,杜 啟泓,刘 耀南,劉 耀南,袁 国勇,袁 國勇
申请号：
TW105122118
公开号：
TW201718009A
申请日:
2016.07.13
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
Compositions and methods are described in which the topical application of a toll-like receptor 7 agonist or a toll-like receptor 9 agonist at or near a subdermal vaccination site provides an enhanced response to the vaccination. The enhanced response can be an elevated antibody titer relative to an untreated but vaccinated subject, and/or development of cross-species immunity to species not present in the vaccinating composition.本發明公開了組合物及方法，其中在皮下疫苗接種位點或其附近局部施用類鐸受體7促效劑或類鐸受體9促效劑可提供對於疫苗接種增強的反應。增強的反應可以是相對於未經處理但已接受疫苗接種的對象而言升高的抗體力價，及/或發展對於未存在於疫苗接種組合物中的物種的跨種免疫。
