598346 Disclosed is the use of an isolated human anti-TNF? antibody, or an antigen binding portion thereof, in the preparation of a medicament for treating cystitis in a subject, wherein the antibody is an isolated human antibody, or an antigen binding portion thereof, that dissociates from human TNF? with a Kd of 1 x 10-8 M or less and a Koff rate constant of 1 x 10-3 s-1 or less, both determined by surface Plasmon resonance, and neutralizes human TNF? cytotoxicity in a standard in vitro L929 assay with an IC50 of 1 x 10-7 M or less.
