GOODREAU CARRIE L.,SALFELD JOCHEN,ISAKSON PETER C.,GHAYUR TARIQ,BENATUIL LORENZO
申请号：
NZ60304511
公开号：
NZ603045A
申请日:
2011.04.06
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Discloses a humanised binding protein capable of binding to human tumor necrosis factor-alpha (TNF-a), the antibody comprising the CDR regions with the sequences； CDR-H1: DYGVN CDR-H2: IWGDGSTDYDSTLKS CDR-H3: WHHGPVAY CDR-L1: KASQAVSSAVA CDR-L2: WASTRHT CDR-L3: QQHYSTPFT wherein the humanised binding protein comprises a human acceptor framework and has a dissociation constant (kD) of at most 1.56x10^-10 M, as measured by surface plasmon resonance
