California Institute of Technology;Cleave Biosciences, Inc. (Cleave);The University of Kansas
发明人:
Deshaies, Raymond J.,Chou, Tsui-Fen,Schoenen, Frank J.,Li, Kelin,Frankowski, Kevin J.,Aube, Jeffrey,Gerritz, Samuel W.,Zhou, Han-Jie
申请号：
AU2011249859
公开号：
AU2011249859A1
申请日:
2011.05.06
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof.
