Raymond J. Deshaies,Tsui-Fen Chou,Frank J. Schoenen,Kelin Li,Kevin J. Frankowski,Jeffrey Aube,Samuel W. Gerritz,Han-Jie Zhou
申请号：
US13103003
公开号：
US08865708B2
申请日:
2011.05.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof.
