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Substituted pyrazolo [3,4-d] pyrimidine compounds, their preparation and use as sigma receptor ligands
专利权人:
Laboratorios del Dr. Esteve; S.A.
发明人:
DIAZ-FERNANDEZ, José-Luis,ALMANSA, Carme,CORBERA ARJONA, Jordi
申请号:
ES13789810
公开号:
ES2608359T3
申请日:
2013.11.14
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of general formula (I): ** Formula ** in which n is selected from 1, 2, 3 or 4; R1 represents an aryl or heteroaryl radical attached to carbon, selected from the group: ** Formula ** Ra independently represents a hydrogen atom, a C1-C6 alkyl radical, a halogen atom, a C1-C6 haloalkyl radical, -CN, -OR or -SO2R in which R is selected from hydrogen or a C1-C6 alkyl; R2 and R3 independently represent a hydrogen atom; a C1-10 aliphatic radical, branched or unbranched; saturated or unsaturated, optionally at least mono-substituted with a C1-C6 alkyl group, a C3-9 cycloalkyl group, a linear or branched C1-6 alkoxy group, -F, -Cl, -I, -Br, -CF3, -CH2F , - CHF2, -CN, -OH, -SH, -NH2, oxo, - (C>; = O) R ', -SR', -SOR ', -SO2R', -NHR ', -NR'R' ' wherein R 'and optionally R' 'for each substituent independently represent a linear or branched C1-C6 alkyl group; a C3-9 cycloalkyl radical unsubstituted or substituted with a C1-C6 alkyl group, a phenyl group, a benzyl group, a linear or branched C1-C6 alkoxy group, -F, -Cl, -I, -Br, -CF3 , -CH2F, -CHF2, -CN, -OH, -SH, -NH2, oxo, - (C>; = O) R ', -SR', - SOR ', -SO2R', -NHR ', -NR' R '' in which R 'and optionally R' 'for each substituent independently represent a linear or branched C1-6 alkyl group; a branched or unbranched cycloalkyl-C1-10 alkyl group in which either the alkyl group and / or the cycloalkyl group is optionally at least monosubstituted with an F, Cl, Br, I, NH2, SH, OH, SO2, CF3, carboxy, cyano, carbamoyl, nitro, phenyl, benzyl, -SO2NH2, C1-C6 alkyl and / or C1-6 alkoxy; a phenyl radical unsubstituted or substituted with a C1-6 alkyl group, a linear or branched C1-6 alkoxy group, phenyl group, -F, -Cl, -I, -Br, -CF3, -CH2F, -CHF2, - CN, -OH, -SH, -NH2, oxo, - (C>; = O) R ', -SR', -SOR ', -SO2R', -N (C>; = O) OR ', -NHR', - NR'R '' in which R 'and optionally R' 'for each substituent independently represent a linear or branched C1-6 alkyl group; a substituted or unsubstituted substituted or unsubstitu
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