GARG SANJAY,ZANEVELD LOURENS JAN DIRK,JR. ANDERSON ROBERT ANTHONY,WALLER DONALD PAUL
申请号：
HU0301417
公开号：
HU230315B1
申请日:
2001.03.06
申请国别(地区):
HU
年份:
2016
代理人:
摘要：
Antimicrobial and contraceptive compositions and methods which prevent and/or reduce the risk of transmission of sexually transmitted diseases through sexual activity as well as prevent and/or reduce the risk of pregnancy are provided. The compositions contain (1) a matrix-forming agent, (2) a bio-adhesive agent, (3) a buffering agent, (4) optionally a humectant, (5) optionally a preservative, and (6) water； wherein the composition is suitable for application within the vagina； wherein the compositions forms a semisolid matrix on contact with ejaculate (thereby trapping ejaculated microbes and spermatozoa)； wherein the composition causes hardening of cervical mucus (thereby decreasing the probability of sperm entry)； wherein the composition forms a bio-adhesive layer over vaginal surfaces (thereby preventing or reducing the risk of contact of STD-causing microbes with the vaginal surfaces)； wherein the composition maintains an acidic vaginal pH of less than about 5 in the presence of semen ejaculated from the male； and wherein the composition does not significantly impair the natural microbiological balance within the vagina. The antimicrobial and contraceptive compositions may also contain additional antimicrobial and/or contraceptive agents (e.g., nonoxynol-9, octoxynol-9, benzalkonium chloride, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H2SO4-modified mandelic acids, povidone iodine, itraconazole, ketoconazole, metronidazole, clotrimazole, fluconazole, teraconazole, miconazole, tinidazole, iconazole, chloramphenicol, nystatin, cyclopiroxolamine, and the like).
