Donald Paul Waller,Lourens Jan Dirk Zaneveld,Robert Anthony Anderson, Jr.,Sanjay Garg
申请号：
BR0109078
公开号：
BRPI0109078B1
申请日:
2001.03.06
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
"Antimicrobial and contraceptive composition that reduces the risk of transmission of, or infection with, sexually transmitted disease through sexual activity involving a female vagina and a male penis, and a method of reducing the risk of transmission and infection with a sexually transmitted disease. transmitted through sexual activity involving a female's vagina and a male's penis. " Antimicrobial and contraceptive compositions are provided and methods that prevent and / or reduce the risk of transmission of sexually transmitted diseases through sexual activity and that also prevent and / or reduce the risk of pregnancy. the compositions contain (1) a matrix forming agent, (2) a bioadhesive agent, (3) a buffering agent, (4) optionally a humectant, (5) optionally a preservative, and (6) water； the composition being suitable for application to the vagina； wherein the composition forms a semi-solid matrix when in contact with ejaculate (thereby trapping sperm and ejaculate microbes)； the composition causing hardening of cervical mucus (thereby reducing the likelihood of sperm entry)； the composition forms a bioadhesive layer on vaginal surfaces (thereby preventing or reducing the risk of contact of STD-causing microbes with the vaginal surfaces)； wherein the composition maintains an acid vaginal ph of less than about 5 in the presence of male ejaculate semen； and contraceptive compositions may also contain additional antimicrobial and / or contraceptive agents (e.g., nonoxynol-9, octoxynol-9, benzalkonium chloride, phosphorylated hesperidines, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde copolymers, mandibenzene sulfonic acid formaldehyde copolymers, modified with h ~ 2 ~ so ~ 4 ~, povidone iodine, itraconazole, ketoconazole, metronidazole, clotrimazole, fluconazole, teraconazole, miconazole, tinidazole, iconazole, chloramphenicol, nystatin, and cyclopiroxolamine, and the like)."composição antimicrobiana e contraceptiva que reduz o risco de
