BACHOVCHIN, WILLIAM W.,LAI, HUNG-SEN,POPLAWSKI, SARAH E.
申请号：
CA2846852
公开号：
CA2846852A1
申请日:
2012.08.30
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Disclosed are proteasome inhibitors, FAP-activated prodrugs of proteasome inhibitors, and pharmaceutically acceptable salts of the inhibitors and prodrugs. Also disclosed are related pharmaceutical compositions, and methods of using the inhibitors and prodrugs and compositions thereof, for example, in treating cancer or other cell proliferative diseases. In vitro and in vivo methods of quantifying the expression of FAP in a biopsy sample and a mammal, respectively, are also disclosed.
