N-[(2,4-DIFLUOROPHENYL)METHYL]-6-HYDROXY-3-METHYL-5,7-DIOXO-2,3,5,7,11,11a-HEXAHYDRO[1,3]OXAZOLO[3,2-a]PYRIDO[1,2-d]PYRAZINE-8-CARBOXAMIDE HAVING HIV INTEGRASE INHIBITORY ACTIVITY
Brian A. JOHNS,Takashi KAWASUJI,Teruhiko TAISHI,Yoshiyuki TAODA
申请号：
US16400373
公开号：
US20190284208A1
申请日:
2019.05.01
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention is to provide a novol compound (I) shown below, having the anti-virus activity； particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof.(whereinZ1 is NR4；R1 is hydrogen or lower alkyl；X′； is a single bond, a hetoro atom group selected from O, S, SO, SO2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene；R2 is optionally substituted aryl；R3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc； andR4 and Z2 part taken together forms a ring, to form a polycyclic compound； including e.g., a tricyclic or tetracyclic compound.
