您的位置: 首页 > 农业专利 > 详情页

Heterocyclic derivatives as trace amine associated receptors (TAAR)
专利权人:
エフ.ホフマン-ラ;アーゲー;ロシュ;エフ.ホフマン-ラ ロシュ アーゲー
发明人:
ガレイ,グイド,ゴーグレー,アニック,ノークロス,ロジャー,フリジェ,フィリップ,ガレイ,グイド,ゴーグレー,アニック,ノークロス,ロジャー,フリジェ,フィリップ
申请号:
JP2014551584
公开号:
JP2015503600A
申请日:
2013.01.08
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
The present invention provides a compound of formula (I) wherein R1 is a compound represented by formulas (a), (b), (c), (d), (e), (f), (g), (h), (i ), (J) is a 1 or 2 membered heteroaryl group, R2 is hydrogen or halogen, or R1 and R2 together with the carbon atom to which they are attached And may form the following rings: formulas (k), (l), (m), (n), (o), R3 is hydrogen, halogen or lower alkyl, and n is 1 Or R4 is phenyl optionally substituted with 1 or 2 substituents selected from halogen or cyano, or pyridinyl optionally substituted with halogen, or -NH-C which is tetrahydropyran or optionally substituted with halogen O) -phenyl, R5 is hydrogen or halogen, R6-R13 is phenyl optionally substituted with halogen, and R14 is -NH-C (O)-substituted with halogen. R15 is phenyl, lower alkyl substituted with hydrogen or halogen, or halogen, R16 is hydrogen or lower alkoxy, and R17 is lower alkyl substituted with lower alkoxy or halogen. Or optionally pharmaceutically suitable acid addition salts thereof, all racemic mixtures of compounds of formula I, all their corresponding enantiomers and / or optics To isomers as well as all tautomers. The compounds of formula I have good affinity for trace amine associated receptors (TAAR), in particular TAAR1. The compounds of formula I have good affinity for trace amine associated receptors (TAAR), in particular TAAR1. The compounds are used for depression, anxiety disorder, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress related disorders, mental disorders such as schizophrenia, neurological disorders such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, drug dependence, and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy expenditure and assimilation, disorders of body temperature homeostasis and function It can be used for the treatment of dysfunction, sleep and circ
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充