The disclosure provides indazolone compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the disclosure may be useful for treating immunological and oncological conditions.本發明提供吲唑酮化合物、其醫藥學上可接受之鹽、前藥、生物學活性代謝物、立體異構體及異構體,其中變數如本文中定義。本發明之化合物可適用於治療免疫及腫瘤病狀。