THE CHILDREN'S MEDICAL CENTER CORPORATION;MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人:
Daniel G. Anderson,Zhen Gu,Alex Arthur Aimetti,Robert S. Langer
申请号：
US14787652
公开号：
US20160067190A1
申请日:
2014.04.29
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A system for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through an injectable nano-network consisting of oppositely-charged dextran nanoparticles encapsulating insulin and glucose-specific enzymes forming a gel-like 3D scaffold. As demonstrated by the examples, the system effectively dissociates to release insulin in a hyperglycemic condition, where the catalytic conversion of glucose into gluconic acid and the subsequent degradation of polymeric matrix are facilitated. This formulation design provides a delivery strategy for both self-regulated and long-term diabetes management.
